Differential Presynaptic ATP Supply for Basal and High-Demand Transmission
نویسندگان
چکیده
منابع مشابه
Differential Presynaptic ATP Supply for Basal and High-Demand Transmission.
The relative contributions of glycolysis and oxidative phosphorylation to neuronal presynaptic energy demands are unclear. In rat hippocampal neurons, ATP production by either glycolysis or oxidative phosphorylation alone sustained basal evoked synaptic transmission for up to 20 min. However, combined inhibition of both ATP sources abolished evoked transmission. Neither action potential propaga...
متن کاملMechanisms that match ATP supply to demand in cardiac pacemaker cells during high ATP demand.
The spontaneous action potential (AP) firing rate of sinoatrial node cells (SANCs) involves high-throughput signaling via Ca(2+)-calmodulin activated adenylyl cyclases (AC), cAMP-mediated protein kinase A (PKA), and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent phosphorylation of SR Ca(2+) cycling and surface membrane ion channel proteins. When the throughput of this signalin...
متن کاملsupply and demand security of energy in central asia and the caucasus
امنیت انرژی به معنی عرضه مداوم و پایدار همراه با قیمت های معقول در حامل های انرژی، که تهدیدات امنیتی، سیاسی، اقتصادی، محیط زیستی و روانی را کاهش دهد. امروزه نفت و گاز تنها، کالای تجاری نیست بلکه بعنوان ابزار سیاسی مورد استفاده قرار می گیرد.اختلاف میان روسیه و اکراین بر سر انرژی در ژانویه 2006، تهدیدی برای امنیت انرژی اروپا ایجاد کرد. در این تحقیق ما تلاش کردیم که نقش انرژی آسیای میانه و قفقاز ر...
15 صفحه اولCALL FOR PAPERS Mitochondria in Cardiovascular Physiology and Disease Mechanisms that match ATP supply to demand in cardiac pacemaker cells during high ATP demand
Yaniv Y, Spurgeon HA, Ziman BD, Lyashkov AE, Lakatta EG. Mechanisms that match ATP supply to demand in cardiac pacemaker cells during high ATP demand. Am J Physiol Heart Circ Physiol 304: H1428 –H1438, 2013. First published April 19, 2013; doi:10.1152/ajpheart.00969.2012.—The spontaneous action potential (AP) firing rate of sinoatrial node cells (SANCs) involves high-throughput signaling via Ca...
متن کاملATP as a presynaptic modulator.
There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy, the observations that ATP is released from stimulated central nervous system (CNS) nerve terminals and that responses to exogenously added ATP can be recorded in central...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2017
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.2712-16.2017